Institute for Environmental Sciences
University of Shizuoka
We Light Up a Shadow of Material Civilization from the Viewpoint of Chemistry
High Precise Evaluation and Prediction of Negative Impacts Induced by Various
Unintentional Products on Our Health through Food-Resource and Environment
1. Study on determination, synthesis, and toxicity of novel organic micropollutants in the environment.
Organic micropollutants such as pharmaceuticals and personal care products (PPCPs) have been an emerging issue in aquatic environment for several decades. We have investigated chemical and toxicological properties for novel PPCPs using instrumental analysis (GC-MS, LC-MS, NMR etc.), standard synthesis, and bioassays. Our recent studies have shown that occurrences of parabens (preservative) and aromatic sensitizers (printing-related material) in the river water, soil, and aquatic biota. We have also evaluated the potential for impacts of PPCPs including their transformation products by photo, chlorination, metabolism, and other environmental factors on aquatic ecosystems.
2. High precise evaluation of biological activity caused by UPs transformed
from organophosphorus compounds.
Organophosphorus compounds, which are well known as useful agrochemicals such as insecticide, are helpful of us to supply crops stably. On the other hand, we have been concerned that they and their relatives induce negative and serious impacts on biological and ecological systems. To clarify these impacts, we have carried out the evaluation from various angles by using bioassays and/or virtual screenings. In addition, we have also attempted to create new materials by using monothiophosphate groups.
3. Elucidation of thermodynamic relationships on the basis of molecular
We have attempted to elucidate statistical thermodynamic relationships such as enthalpy and entropy compensation, or isokinetic/isoequilibrium effects on the basis of molecular structure and its topological characteristics by using isothermal gas chromatography.
We hope that the results and revealed relationships are useful for estimating the risk of various environmental chemicals on human health and ecological system as well as useful for understanding the fate and the persistence of them, and that our research themes attract the interest of many students and they join in our research projects!